BenzenaMine, 4-iodo-2,6-diMethyl-

Name	4-Iodo-2,6-dimethylaniline
Synonyms	4-Iod-2,6-dimethylanilin 4-iod-2,6-dimethylanilin 4-IODO-2,6-DIMETHYLANILINE 4-Iodo-2,6-dimethylaniline 4-iodo-2,6-dimethylbenzenamine benzenamine, 4-iodo-2,6-dimethyl- BenzenaMine, 4-iodo-2,6-diMethyl- 4-Iodo-2,6-dimethylaniline( 4-Iodo-2,6-xylidine)
CAS	4102-53-8 138385-59-8
EINECS	609-884-8
InChI	InChI=1/C8H10IN/c1-5-3-7(9)4-6(2)8(5)10/h3-4H,10H2,1-2H3

Molecular Formula	C8H10IN
Molar Mass	247.08
Density	1.688±0.06 g/cm3(Predicted)
Melting Point	52 °C
Boling Point	120 °C(Press: 0.998 Torr)
Flash Point	129.6°C
Vapor Presure	0.00204mmHg at 25°C
pKa	3.51±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.644
Use	This product is for scientific research only and shall not be used for other purposes.

Overview	4-iodo-2, 6-dimethylaniline is an organic intermediate, which can be prepared from 2, 6-dimethylaniline iodide. The amino group of 4-iodo-2, 6-dimethylaniline can be prepared by diazotization dimethyl-to-bromoiodobenzene.
application	4-iodine -2, 6-dimethylaniline is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
preparation	12.7g(0.05mol) of fully ground iodine, 40mL of ethyl acetate and 50mL of acetic acid are added to a 250mL three-neck flask, 7.5g(0.054mol) of SPC is added in batches under stirring, and the addition is completed within 20min. Add 2, 6-dimethylaniline 12.4mL(0.1mol), stir at 20~25 ℃ for 0.5h, raise the temperature to 45~50 ℃, and reflow for 1h. After cooling, the mixture is poured into an aqueous solution of 200mL w(Na2SO3)= 5%, and after full stirring, the organic phase is evaporated to the solvent under reduced pressure to obtain a black-purple solid crude product, and the white acicular crystal 4-iodine -2, 6-dimethylaniline is recrystallized by n-hexane 10.5g, and the yield is 42.5%.

Last Update：2024-04-09 15:16:50

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